Calretinin: from a “simple” Ca2+ buffer to a multifunctional protein implicated in many biological processes

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Calretinin: from a “simple” Ca2+ buffer to a multifunctional protein implicated in many biological processes

The hexa-EF-hand Ca(2+)-binding protein calretinin (CR) is predominantly expressed in specific neurons of the central and peripheral nervous system. However, CR expression is also observed in non-neuronal cells, e.g., during embryonic development and in mesothelioma cells. Of the 6 EF-hand domains, 5 are functional; the first 4 domains form 2 pairs showing high cooperativity within a pair that ...

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ژورنال

عنوان ژورنال: Frontiers in Neuroanatomy

سال: 2014

ISSN: 1662-5129

DOI: 10.3389/fnana.2014.00003